[Significance of histologic bone marrow evaluation in diagnosis of chronic granulocytic leukemia. II. Megakaryocytes].

In 40 non-treated, ph1-positive patients with chronic granulocytic leukaemia (CGL) statistically significant correlation between the number of megakaryocytes and Sokal's index was found. The comparison of the data concerning megakaryocytic-granulocytic type (with increased number of megakaryocytes) CGL and granulocytic type (classical) revealed that patients with increased number of megakaryocytes in bone marrow had significantly greater spleen, larger number of leukocytes, platelets and myeloblasts in peripheral blood, more advanced bone marrow fibrosis and higher Sokal's index. These data seem to suggest that patients with megakaryocytic-granulocytic type of CGL have worse prognosis than with classical type.