Jedrzejczak W W
Zakładu Immunologii CSK WAM w Warszawie.
Acta Haematol Pol. 1995;26(2 Suppl 1):25-33.
In the article the basic knowledge concerning genes and genetic disorders necessary to understand the methods utilized in contemporary attempts of gene therapy has been reviewed. Then, a classification of gene therapy methods was presented and approaches to somatic gene therapy were discussed with particular attention to the utilization of retroviral vectors and packaging cell lines. Other vector systems such as adenovirus, vaccinia virus, and herpes virus derived have also been mentioned as well as antisense strategy. Reviewed applications concerned mainly inborn gene errors, but strategy of gene-directed, gene-forced suicide of leukemic cells has also been mentioned.
本文回顾了理解当代基因治疗方法所必需的有关基因和遗传疾病的基础知识。然后，介绍了基因治疗方法的分类，并讨论了体细胞基因治疗方法，特别关注逆转录病毒载体和包装细胞系的应用。还提到了其他载体系统，如腺病毒、痘苗病毒和疱疹病毒衍生载体，以及反义策略。所回顾的应用主要涉及先天性基因缺陷，但也提到了基因导向的白血病细胞自杀策略。
