Nakamura S, Arakawa S, Nishiike S
Department of Physiology, Faculty of Medicine, Kanazawa University, Japan.
Am J Physiol. 1995 Aug;269(2 Pt 2):R236-44. doi: 10.1152/ajpregu.1995.269.2.R236.
The influence of the dam's brain on the electrical activity of brain neurons was examined in the rat fetus while the fetus was still connected to the dam by the umbilical cord. Under urethan anesthesia, the spontaneous or glutamate-induced discharge of single brain stem neurons in fetuses was decreased by electrical stimulation of the dam's hypothalamus (Hyp). The changes occurred 21-122 s after start of the stimulation and persisted throughout the recording until the cells were lost after 2.4-9.5 min. The effects of electrical stimulation of dam's midbrain reticular formation (MRF) were much weaker and of shorter duration compared with Hyp stimulation. The dam's blood pressure was increased immediately after the beginning of MRF or Hyp stimulation. The change was always greater with MRF than with Hyp stimulation. Activation of the dam's MRF and Hyp had no marked influence on the blood flow in the fetal brain. These results indicate the presence of a functional interaction between the brain of the dam and that of its fetus mediated through the placenta.
在大鼠胎儿仍通过脐带与母体相连时，研究了母体大脑对胎儿脑神经元电活动的影响。在乌拉坦麻醉下，通过电刺激母体下丘脑（Hyp），可使胎儿单个脑干神经元的自发放电或谷氨酸诱导放电减少。这些变化在刺激开始后21 - 122秒出现，并在整个记录过程中持续存在，直到细胞在2.4 - 9.5分钟后消失。与Hyp刺激相比，电刺激母体中脑网状结构（MRF）的效果要弱得多，且持续时间更短。MRF或Hyp刺激开始后，母体血压立即升高。MRF刺激引起的变化总是比Hyp刺激时更大。激活母体的MRF和Hyp对胎儿脑血流没有明显影响。这些结果表明，母体大脑与其胎儿大脑之间存在通过胎盘介导的功能相互作用。
