Tariot P N, Mack J L, Patterson M B, Edland S D, Weiner M F, Fillenbaum G, Blazina L, Teri L, Rubin E, Mortimer J A
University of Rochester School of Medicine, N.Y., USA.
Am J Psychiatry. 1995 Sep;152(9):1349-57. doi: 10.1176/ajp.152.9.1349.
The purpose of the study was to develop a standardized instrument, the Behavior Rating Scale for Dementia, for rating psychopathology in patients with probable Alzheimer's disease and to conduct a multicenter pilot study of this instrument.
The rating scale was developed collaboratively on the basis of clinical experience and existing instruments. Items were scaled according to frequency of psychopathology and were administered to an informant who was familiar with the subject. The scale was administered in a standardized manner by trained examiners who had met predetermined certification standards. The study group consisted of 303 subjects with probable Alzheimer's disease who had undergone standardized clinical evaluations by the Consortium to Establish a Registry for Alzheimer's Disease.
Subjects had an average of 15 problems rated as present in the preceding month. Wide variability in the nature of disturbances was found, with a number of items rated as present since the illness began but not in the past month. Interrater agreement was high. Factor analysis suggested eight preliminary factors that mapped onto clinically relevant domains: depressive features, psychotic features, defective self-regulation, irritability/agitation, vegetative features, apathy, aggression, and affective lability.
The Behavior Rating Scale for Dementia provides a standardized, reliable measure that can be administered to caregivers of demented subjects. On the basis of the present study, the scale has been revised slightly. After additional studies in progress, the Behavior Rating Scale for Dementia will be available for general use in assessing a wide range of psychopathology in dementia.
本研究旨在开发一种标准化工具——痴呆行为评定量表，用于对可能患有阿尔茨海默病的患者的精神病理学进行评定，并对该工具进行多中心试点研究。
该评定量表是在临床经验和现有工具的基础上合作开发的。项目根据精神病理学的发生频率进行评分，并由熟悉受试者情况的知情者进行评定。该量表由符合预定认证标准的经过培训的检查人员以标准化方式进行评定。研究组由303名可能患有阿尔茨海默病的受试者组成，这些受试者均接受了阿尔茨海默病注册协会的标准化临床评估。
受试者在前一个月平均有15个被评定为存在的问题。发现干扰的性质存在很大差异，许多项目自疾病开始就被评定为存在，但在过去一个月中并非如此。评分者间的一致性很高。因子分析表明有八个初步因子，这些因子对应于临床相关领域：抑郁特征、精神病性特征、自我调节缺陷、易激惹/激越、植物神经功能特征、淡漠、攻击行为和情感不稳定。
痴呆行为评定量表提供了一种标准化、可靠的测量方法，可用于对痴呆患者的照料者进行评定。基于本研究，该量表已进行了轻微修订。在正在进行的进一步研究之后，痴呆行为评定量表将可广泛用于评估痴呆患者的各种精神病理学表现。
