Jiang W G, Hiscox S, Hallett M B, Mansel R E, Puntis M C
University Department of Surgery, University of Wales College of Medicine, Cardiff, UK.
Anticancer Res. 1995 Jul-Aug;15(4):1303-10.
Tumour tissues are frequently seen with monocyte/macrophage infiltration. This study was to establish the role of monocytes on the motile and invasive behaviour of human cancer cells. By using a co-culture technique, we have shown that both human peripheral blood monocytes and a monocytic cell line, U937, stimulated colon and breast cancer cell colony scattering, motility, and invasion into a basement membrane (Matrigel). This effect was enhanced when monocytic cells were stimulated by a particulate stimulus. IL-4 and IL-10 reduced these effects of monocytes. We conclude that monocytic cells enhance the motility and invasion of tumour cells. These effects can be regulated by inhibitory cytokines of monocytes.
肿瘤组织中经常可见单核细胞/巨噬细胞浸润。本研究旨在确定单核细胞在人类癌细胞运动和侵袭行为中的作用。通过使用共培养技术，我们发现人类外周血单核细胞和单核细胞系U937均能刺激结肠和乳腺癌细胞集落分散、运动以及侵袭基底膜（基质胶）。当单核细胞受到颗粒刺激时，这种作用会增强。白细胞介素-4和白细胞介素-10可降低单核细胞的这些作用。我们得出结论，单核细胞可增强肿瘤细胞的运动和侵袭能力。这些作用可由单核细胞的抑制性细胞因子调节。
