Jasonni V M, Amadori A, Santini D, Ceccarelli C, Naldi S, Flamigni C
Department of Obstetrics and Gynecology, S. Orsola General Hospital, University of Bologna, Italy.
Anticancer Res. 1995 Jul-Aug;15(4):1327-32.
The role of epidermal growth factor receptor (EGF-R) and transforming growth factor alpha (TGFA) in endometrial cancer is still controversial. In this study the immunostaining of EGF-R and TGFA, investigated in 44 cases, proved to be related to endometrial cancer histotype regardless of the tumor grade or the extent of myometrial invasion. In fact, EGF-R expression was observed in 12.5% (1/8) of cases with classical endometrioid adenocarcinoma, in 91% (10/11) with endometrial adenocarcinoma and benign squamous metaplasia, and in 35% (6/17) with adenosquamous carcinoma. TGFA expression was concomitant with EGF-R in the first two histotypes, and was present in about 50% (9/17) of the latter. Conversely, in mucinous and serous papillary adenocarcinoma, EGF-R and TGFA immunostaining was not observed. In conclusion, EGF-R positivity was observed in endometrial cancer with squamous differentiation, especially in those cases with benign squamous metaplasia. EGF-R and TGFA coexpression appeared as a constant feature of benign squamous metaplasia.
表皮生长因子受体（EGF-R）和转化生长因子α（TGFA）在子宫内膜癌中的作用仍存在争议。在本研究中，对44例病例进行的EGF-R和TGFA免疫染色研究表明，其与子宫内膜癌组织类型相关，而与肿瘤分级或肌层浸润程度无关。事实上，在12.5%（1/8）的经典子宫内膜样腺癌病例、91%（10/11）的伴有良性鳞状化生的子宫内膜腺癌病例以及35%（6/17）的腺鳞癌病例中观察到了EGF-R表达。在前两种组织类型中，TGFA表达与EGF-R同时出现，并且在后者中约50%（9/17）存在。相反，在黏液性和浆液性乳头状腺癌中未观察到EGF-R和TGFA免疫染色。总之，在伴有鳞状分化的子宫内膜癌中观察到EGF-R阳性，尤其是在那些伴有良性鳞状化生的病例中。EGF-R和TGFA共表达似乎是良性鳞状化生的一个恒定特征。
