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[呋喃唑酮和二呋拉西(PAP - 49)在实验性葡萄球菌和大肠杆菌败血症中的治疗效果]

[Therapeutic effectiveness of furazolidone and difuracil (PAP-49) in experimental staphylococcal and Escherichia septicemia].

作者信息

Terekhov V I, Pavlov P A

出版信息

Antibiot Khimioter. 1995 Apr;40(4):37-9.

PMID:7654099
Abstract

The therapeutic efficacy of a new nitrofuran, N-(5-nitrofurilidene)-5-nitrofuran-2-(N'-acetyl)carboxamidra zone (difuracil or PAP-49) in experimental staphylococcal and Coli septicemia was stated and compared to that of furazolidone. It was shown in the models of staphylococcal and Coli septicemia of albino mice that by its therapeutic efficacy difuracil (PAP-49) was 1.3 times more active as furazolidone and by 1-2 days earlier eradicated the pathogens in the host.

摘要

一种新型硝基呋喃类药物,N-(5-硝基糠叉基)-5-硝基呋喃-2-(N'-乙酰基)羧酰胺腙(双呋辛或PAP-49)在实验性葡萄球菌性和大肠杆菌性败血症中的治疗效果得到了阐述,并与呋喃唑酮的治疗效果进行了比较。在白化小鼠的葡萄球菌性和大肠杆菌性败血症模型中显示,就治疗效果而言,双呋辛(PAP-49)比呋喃唑酮的活性高1.3倍,并且能提前1 - 2天清除宿主体内的病原体。

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