小脑切除对大鼠大脑皮质青霉素致痫灶的影响。

The effects of cerebellectomy on a penicillin epileptogenic focus in the cerebral cortex of the rat.

作者信息

Gartside I B

出版信息

Electroencephalogr Clin Neurophysiol. 1978 Mar;44(3):373-9. doi: 10.1016/0013-4694(78)90312-7.

Abstract

(1) Total removal of the cerebellum from the rat anaesthetised with urethane was found to increase the duration of epileptiform foci produced by injection of 25 U of Penicillin into the cerebral cortex. (2) This was not due to reduction in blood pressure nor to non-specific brain damage resulting from the cerebellectomy. (3) The effects of total cerebellectomy are not due to the removal of the inhibitory influence of the Purkinje cells on the intracerebellar nuclei, which from part of an excitatory cortico-cortical circuit. (4) The underlying mechanism is obscure, but it is possible that the cerebellum produces some inhibitory tone, which decreases the lifetime of penicillin foci.

摘要

(1) 发现从用乌拉坦麻醉的大鼠中完全切除小脑，会增加向大脑皮层注射25单位青霉素所产生的癫痫样病灶的持续时间。(2) 这并非由于血压降低，也不是由于小脑切除导致的非特异性脑损伤。(3) 完全小脑切除的影响并非由于去除了浦肯野细胞对小脑内神经核的抑制作用，而小脑内神经核构成了兴奋性皮质 - 皮质回路的一部分。(4) 潜在机制尚不清楚，但有可能小脑产生某种抑制性张力，从而缩短青霉素病灶的持续时间。