Pauken C M, Lo C W
Department of Biology, University of Pennsylvania, Philadelphia 19104-6017, USA.
Mol Reprod Dev. 1995 Jun;41(2):195-203. doi: 10.1002/mrd.1080410210.
We characterized the expression of two gap junction genes (Cx26 and Cx43) in the mouse decidua and placenta. In the decidua, in situ hybridization analysis and immunostaining studies revealed a high level of Cx43 expression. In contrast, Cx26 expression was not detected. Analysis of the placenta revealed that both Cx43 and Cx26 transcripts are expressed, but in nonoverlapping cell populations. Cx26 transcripts were observed only in the labyrinthine trophoblast layer of the placenta, a tissue of ectoplacental cone derivation. In contrast, no Cx43 transcripts were found in the placenta proper, but only in the maternally derived decidual cap covering the placenta. These results, in conjunction with previous observations in the mouse and rat, indicate that there may be species-specific differences in the pattern of Cx43/Cx26 expression in the placenta and decidua.
我们对小鼠蜕膜和胎盘中两个间隙连接基因（Cx26和Cx43）的表达进行了表征。在蜕膜中，原位杂交分析和免疫染色研究显示Cx43表达水平较高。相比之下，未检测到Cx26表达。胎盘分析表明，Cx43和Cx26转录本均有表达，但在不重叠的细胞群体中。仅在胎盘迷路滋养层（一种外胎盘锥体来源的组织）中观察到Cx26转录本。相比之下，在胎盘本身未发现Cx43转录本，仅在覆盖胎盘的母体来源的蜕膜帽中发现。这些结果与之前在小鼠和大鼠中的观察结果相结合，表明胎盘和蜕膜中Cx43/Cx26表达模式可能存在物种特异性差异。
