一种新的保存液：Celsior在离体大鼠肺中的评估。巴黎南大学肺移植组。
Evaluation of a new preservation solution: Celsior in the isolated rat lung. Paris-Sud University Lung Transplatation Group.
作者信息
Reignier J, Mazmanian M, Chapelier A, Alberici G, Ménasché P, Weiss M, Hervé P
机构信息
Laboratoire de Chirurgie Expérimentale, Centre chirurgical Marie Lannelongue, Plessis-Robinson, France.
出版信息
J Heart Lung Transplant. 1995 May-Jun;14(3):601-4.
BACKGROUND
We compared Celsior solution, a new and original extracellular preservation solution, with blood-based Wallwork's solution.
METHODS
In two groups of isolated rat lungs submitted to 4 hours of cold ischemia, pulmonary arterial and venous resistances, coefficient of filtration, and wet-to-dry lung weight ratio were determined at baseline and after 90 minutes of reperfusion.
RESULTS
After ischemia-reperfusion, percentage of increases above the respective baseline coefficient of filtration values were 93% +/- 7% in the Wallwork group and 7% +/- 3% in the Celsior group (p < 0.001 versus Wallwork's solution).
CONCLUSIONS
These results show that Celsior consistently prevented the ischemia-reperfusion-induced increase in pulmonary microvascular permeability as compared with Wallwork's solution.
背景
我们将一种新型原创细胞外保存液Celsior溶液与基于血液的Wallwork溶液进行了比较。
方法
在两组接受4小时冷缺血的离体大鼠肺中，于基线时以及再灌注90分钟后测定肺动脉和静脉阻力、滤过系数以及肺湿重与干重之比。
结果
缺血再灌注后，Wallwork组滤过系数值相对于各自基线值的增加百分比为93%±7%，Celsior组为7%±3%（与Wallwork溶液相比，p<0.001）。
结论
这些结果表明，与Wallwork溶液相比，Celsior能持续预防缺血再灌注引起的肺微血管通透性增加。
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