Lippman S M, Spitz M R, Huber M H, Hong W K
University of Texas MD Anderson Cancer Center, Department of Thoracic/Head and Neck Medical Oncology, Houston 77030, USA.
Curr Opin Oncol. 1995 May;7(3):234-41. doi: 10.1097/00001622-199505000-00008.
Recent strides in epidemiology (mutagen sensitivity assays) and basic molecular study of head and neck carcinogenesis are advancing chemoprevention in the head and neck. The clinical preventive activity of retinoids, the most studied and most active chemopreventive agents in this region, has been established in six randomized head and neck trials. Ongoing translational study of the p53 gene, nuclear retinoid receptors, and other cellular and molecular biomarkers will be necessary to achieve continuing progress in head and neck cancer chemoprevention.
近期在流行病学（诱变敏感性检测）以及头颈部癌发生的基础分子研究方面取得的进展，正在推动头颈部的化学预防。维甲酸是该领域研究最多且活性最强的化学预防剂，其临床预防活性已在六项头颈部随机试验中得到证实。为了在头颈部癌化学预防方面持续取得进展，对p53基因、核维甲酸受体以及其他细胞和分子生物标志物进行持续的转化研究将是必要的。
