Bass J W, Crast F W, Knowles C R, Onufer C N
JAMA. 1976 Mar 15;235(11):1112-6. doi: 10.1001/jama.235.11.1112.
Four hundred children with streptococcal pharyngitis were treated randomly with single injections in groups of 100 each (1) with 600,000 units of penicillin G benzathine, (2) 1.2 million units of penicillin G benzathine, (3) 600,000 units of penicillin G benzathine and 600,000 units of penicillin G procaine, or (4) 900,000 units of penicillin G benzathine and 300,000 units of penicillin G procaine. Clinical response and severity of local reaction were judged in a double-blind manner at 24, 48, and 72 hours; throat cultures were taken then, and at 10, 21, and 42 days. Although the clinical response to 900,000 units of penicillin G benzathine and 300,000 units of penicillin G procaine was equal to 1.2 million units of penicillin G benzathine, the former cleared the streptococci more quickly, greatly reduced the incidence and severity of local reactions, and offered optimal therapy for streptococcal pharyngitis in the pediatric age group.
400名患有链球菌性咽炎的儿童被随机分成每组100人的四个组进行单次注射治疗：（1）注射60万单位苄星青霉素G；（2）注射120万单位苄星青霉素G；（3）注射60万单位苄星青霉素G和60万单位普鲁卡因青霉素G；（4）注射90万单位苄星青霉素G和30万单位普鲁卡因青霉素G。在24、48和72小时以双盲方式判断临床反应和局部反应的严重程度；随后以及在第10、21和42天采集咽喉培养样本。虽然90万单位苄星青霉素G和30万单位普鲁卡因青霉素G的临床反应与120万单位苄星青霉素G相当，但前者清除链球菌的速度更快，极大地降低了局部反应的发生率和严重程度，为儿童年龄组的链球菌性咽炎提供了最佳治疗方案。
