Maruta A, Matsuzaki M, Miyashita H, Kodama F, Kato H, Taguchi J, Tomita N, Sakai R, Fujisawa S, Okubo T
Department of Haematology/Chemotherapy, Kanagawa Cancer Center, Yokohama, Japan.
Bone Marrow Transplant. 1995 Apr;15(4):637-8.
A 23-year-old woman had a normal full-term delivery 78 months after BMT for ALL. Conditioning therapy was Ara C 1.4 g/m2 x 4, CY 60 mg/kg x 2 and TBI 2.5 Gy x 5 at a dose rate of 3.5 cGy/min. Despite GVHD prophylaxis with short-term MTX and CsA, she developed grade I acute GVHD, but showed no evidence of chronic GVHD. Following amenorrhea for 4 years, menstruation recommenced spontaneously. She had a normal pregnancy 6 years after BMT resulting in a healthy infant with simple hypospadias. This and previous reports indicate that normal pregnancy is possible after BMT with TBI in excess of 10 Gy.
