使用抗Rh D单克隆抗体开发和评估一种竞争性放射免疫测定法，用于测定临床级免疫球蛋白制剂的抗-D效价。
Development and evaluation of a competitive radioimmunoassay using monoclonal antibodies against Rh D for determining anti-D potency of clinical grade immunoglobulin preparations.
作者信息
Thorpe S J, Heath A B
机构信息
National Institute for Biological Standards and Control, Potters Bar, Herts., U.K.
出版信息
Transfus Med. 1995 Jun;5(2):97-103. doi: 10.1111/j.1365-3148.1995.tb00195.x.
Abstract
A competitive radioimmunoassay using monoclonal anti-D antibodies has been developed for measuring anti-D activity in prophylactic immunoglobulin preparations. The assay is totally specific for anti-D, reproducible and gives potency estimates comparable to those determined using autoanalyzer methodology. The assay also provides a means for comparing different batches of monoclonal anti-D preparations for red-cell binding activity.
摘要
已开发出一种使用单克隆抗-D抗体的竞争性放射免疫测定法，用于测量预防性免疫球蛋白制剂中的抗-D活性。该测定法对抗-D具有完全特异性，可重复，并且给出的效价估计值与使用自动分析仪方法测定的结果相当。该测定法还提供了一种比较不同批次单克隆抗-D制剂红细胞结合活性的方法。
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