Jenkins P G, Coombes A G, Yeh M K, Thomas N W, Davis S S
Proteus Molecular Design Ltd., Cheshire.
J Drug Target. 1995;3(1):79-81. doi: 10.3109/10611869509015939.
Mortality and morbidity data continue to indicate there is a compelling need for the derivation of a new generation of vaccine delivery systems that can be usefully applied via injection and also mucosally. One technology that has potential for design as an effective vaccine delivery system is the formulation of biodegradable microparticles from the polymers and poly lactide co-glycolide (PLGA) in particular. The potential advantages of the delivery of vaccines within such microparticles is discussed. The potential for eliciting and optimising immunity after the mucosal delivery of biodegradable microparticles is also discussed.
死亡率和发病率数据持续表明，迫切需要研发新一代疫苗递送系统，该系统既能通过注射有效应用，也能通过黏膜途径应用。一种有潜力设计成有效疫苗递送系统的技术，特别是由聚合物尤其是聚乳酸-乙醇酸共聚物（PLGA）制备可生物降解的微粒制剂。本文讨论了在这类微粒中递送疫苗的潜在优势。还讨论了可生物降解微粒经黏膜递送后激发和优化免疫的潜力。
