Haider A, Miller D R, Christenson J L, Cushing A G, Station R D
University of Saskatchewan, Saskatoon, Canada.
Am J Health Syst Pharm. 1995 Jun 15;52(12):1317-9. doi: 10.1093/ajhp/52.12.1317.
The effect of replacing fluoxetine with sertraline at two dosage-conversion ratios was studied. Outpatients at a Veterans Affairs mental health clinic who were being treated with fluoxetine were randomly assigned to receive either 50 or 75 mg of sertraline hydrochloride for every 20 mg of fluoxetine (as the hydrochloride salt) or to continue to receive their current dosage of fluoxetine. The subjects were given the Hamilton Depression Rating Scale (HDRS) and the Beck Depression Inventory (BDI) at baseline and were re-examined at one-month intervals for three months with the HDRS and BDI and the Clinical Global Impression of Change. Each patient was re-evaluated by the same blinded investigator. A total of 45 patients (42 men and 3 women) completed the study. The final overall response did not differ significantly among the three groups. There were also no significant differences among the groups in the proportions of patients with HDRS and BDI scores classified as improving, worsening, or not changing. Improvement was more common in patients receiving the higher dosage of sertraline. Few adverse effects were reported. Outpatients receiving fluoxetine were switched to sertraline therapy without a loss of control of depression and without substantial adverse effects.
研究了两种剂量转换比例下用舍曲林替代氟西汀的效果。在一家退伍军人事务部心理健康诊所接受氟西汀治疗的门诊患者被随机分配，每20毫克氟西汀（盐酸盐形式）接受50毫克或75毫克盐酸舍曲林，或者继续接受当前剂量的氟西汀。在基线时对受试者进行汉密尔顿抑郁量表（HDRS）和贝克抑郁量表（BDI）评估，并在三个月内每隔一个月用HDRS、BDI和临床总体印象变化量表进行复查。每位患者由同一位不知情的研究者重新评估。共有45名患者（42名男性和3名女性）完成了研究。三组之间的最终总体反应无显著差异。在HDRS和BDI评分被分类为改善、恶化或未改变的患者比例方面，各组之间也没有显著差异。接受较高剂量舍曲林的患者改善更为常见。报告的不良反应很少。接受氟西汀治疗的门诊患者转换为舍曲林治疗后，抑郁并未失控，也没有出现严重不良反应。
