高血糖持续时间对兔角膜厚度和内皮ATP酶活性的影响。
Effect of hyperglycemia duration on rabbit corneal thickness and endothelial ATPase activity.
作者信息
Herse P, Adams L
机构信息
Department of Optometry, University of Auckland, New Zealand.
出版信息
Acta Ophthalmol Scand. 1995 Apr;73(2):158-61. doi: 10.1111/j.1600-0420.1995.tb00659.x.
This study compares corneal thickness and corneal endothelial Na,K ATPase activity in normal and age-matched diabetic rabbits with up to 10 weeks of hyperglycemia. Corneal endothelial Na,K ATPase activity in normal rabbits increased between 10 and 20 weeks of age. Corneal thickness increased after 5 weeks of hyperglycemia. Decreased corneal endothelial homogenate Na,K ATPase activity was first seen after 10 weeks of hyperglycemia, though an earlier onset was possible due to sampling restrictions. Corneal endothelial homogenate Mg++ ATPase activity showed a transient increase after 2 to 5 weeks of hyperglycemia. This study shows that hyperglycemia in rabbit is associated with complex dynamic interactions between corneal thickness and corneal endothelial Mg++ ATPase and Na,K ATPase activities.
本研究比较了正常和年龄匹配的糖尿病兔在长达10周高血糖状态下的角膜厚度和角膜内皮钠钾ATP酶活性。正常兔角膜内皮钠钾ATP酶活性在10至20周龄之间增加。高血糖5周后角膜厚度增加。高血糖10周后首次出现角膜内皮匀浆钠钾ATP酶活性降低，不过由于取样限制，可能更早出现这种情况。高血糖2至5周后角膜内皮匀浆镁离子ATP酶活性出现短暂增加。本研究表明，兔体内的高血糖与角膜厚度、角膜内皮镁离子ATP酶和钠钾ATP酶活性之间复杂的动态相互作用有关。
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