Zhen Z, Guo Y, Zhang Z
44th Hospital, Guiyang.
Zhonghua Yi Xue Za Zhi. 1995 May;75(5):266-9, 318.
Of 180 patients with coronary heart disease (CHD) 43 (23.9%) showed in microthrombi conjunctival microcirculation. We compared the healthy subjects with the patients with microthrombi and thrombi-free as well as with the patients with microthrombi pre- and post-treatment of heparin or salvia miltiorrhizae. The formation and the number of microthrombi in the CHD patients were closely related to symptoms, ECGS, plasma TXB2, 6-kero-PGF1a and other indexes on hemodynamics. Follow-up of the patients with microthrombi revealed that their death rate was higher than that of CHD patients without microthrombi, especially in the sudden deaths. We consider that microthrombi may be regarded as an important index of the state, therapeutic efficacy, and prognosis of the CHD patients. The use of heparin may certainly be based on the condition of the microthrombi in the microcirculation of CHD patients.
在180例冠心病（CHD）患者中，43例（23.9%）出现结膜微循环微血栓。我们将健康受试者与有微血栓和无微血栓的患者进行了比较，还将肝素或丹参治疗前后有微血栓的患者进行了比较。冠心病患者微血栓的形成及数量与症状、心电图、血浆TXB2、6-酮-前列腺素F1α及其他血流动力学指标密切相关。对有微血栓患者的随访显示，他们的死亡率高于无微血栓的冠心病患者，尤其是猝死率。我们认为微血栓可被视为冠心病患者病情、治疗效果及预后的重要指标。肝素的使用当然可基于冠心病患者微循环中微血栓的情况。
