疾病与药物治疗对帕金森病患者血液中血清素及单胺氧化酶B活性的影响
Effect of disease and drug treatment on blood serotonin and monoamine oxidase B activity in Parkinson's disease.
作者信息
van Kempen G M, Janjua R, Roos R A
机构信息
Department of Psychiatry, State University Leiden, Oegstgeest, Netherlands.
出版信息
Clin Neurol Neurosurg. 1995 May;97(2):131-3. doi: 10.1016/0303-8467(95)00011-8.
Serotonin (5-hydroxytryptamine, 5HT) content and monoamine oxidase (MAO) activity were determined in whole blood of patients with Parkinson's disease (PD) with and without drug treatment and compared with controls. From that comparison a significant reduction in platelet 5HT became apparent in PD. Selegiline, which was always used in combination with L-dopa, not only inhibited MAO activity, as expected, but it also appeared to induce an increase in 5HT content.
测定了接受药物治疗和未接受药物治疗的帕金森病（PD）患者全血中的血清素（5-羟色胺，5HT）含量和单胺氧化酶（MAO）活性，并与对照组进行比较。通过该比较发现，PD患者血小板5HT含量显著降低。一直与左旋多巴联合使用的司来吉兰，不仅如预期的那样抑制了MAO活性，而且似乎还能使5HT含量升高。
Zotero 插件