Klingelhöfer J, Hajak G, Matzander G, Schulz-Varszegi M, Sander D, Rüther E, Conrad B
Department of Neurology, Technical University of Munich, Germany.
Clin Neurol Neurosurg. 1995 May;97(2):142-8. doi: 10.1016/0303-8467(95)00030-n.
Bilateral flow patterns of the middle cerebral artery (MCA) were recorded continuously throughout the night in 18 healthy male subjects (mean age 27.4 years) by a computer-assisted pulsed Doppler (2 MHz) system together with simultaneous polysomnography. After inception of sleep, mean flow velocity (MFV) decreased steadily during deepening sleep stages reaching -15.0 +/- 3.6% (p < 0.001) in the right MCA and -16.2 +/- 3.4% in the left MCA (p < 0.001) in stage 4 of the first sleep cycle compared to the waking state. Lowest MFV values were found in stage 2 preceding the last REM period (right MCA: -19.2 +/- 4.1%: left MCA: -19.7 +/- 5.1%). Changing from non-REM into REM sleep, a sudden rise of MFV, which varied from 8.9% (first sleep cycle, left MCA) to 18% (last sleep cycle, right MCA), could be consistently detected indicating a coupling of cerebral electrical activity and cerebral perfusion in REM sleep. During non-REM sleep this concomitant change of MFV and EEG activity was only found in the first sleep cycle, whereas no parallel changes could be observed in later sleep cycles. These results indicate a decoupling of EEG measured cerebral electrical activity and perfusion and suggest that factors other than metabolic mechanisms contribute to the regulation of cerebral perfusion during human non-REM sleep.
通过计算机辅助脉冲多普勒（2兆赫）系统并同时进行多导睡眠图监测，在18名健康男性受试者（平均年龄27.4岁）中，连续记录了整个夜间大脑中动脉（MCA）的双侧血流模式。入睡后，在第一个睡眠周期的第4阶段，与清醒状态相比，随着睡眠加深，平均血流速度（MFV）稳步下降，右侧大脑中动脉下降至-15.0±3.6%（p<0.001），左侧大脑中动脉下降至-16.2±3.4%（p<0.001）。最低MFV值出现在最后一个快速眼动期之前的第2阶段（右侧大脑中动脉：-19.2±4.1%；左侧大脑中动脉：-19.7±5.1%）。从非快速眼动睡眠转变为快速眼动睡眠时，可始终检测到MFV突然升高，升高幅度从8.9%（第一个睡眠周期，左侧大脑中动脉）到18%（最后一个睡眠周期，右侧大脑中动脉），这表明快速眼动睡眠中脑电活动与脑灌注之间存在耦合。在非快速眼动睡眠期间，MFV和脑电图活动的这种伴随变化仅在第一个睡眠周期中发现，而在随后的睡眠周期中未观察到平行变化。这些结果表明，脑电图测量的脑电活动与灌注之间存在解耦，并表明在人类非快速眼动睡眠期间，除代谢机制外的其他因素有助于调节脑灌注。
