肼屈嗪对犬毒蕈碱型神经节刺激的作用。

Effects of hydralazine on canine muscarinic ganglion stimulation.

作者信息

Gomer S K, Hilton J G

出版信息

Eur J Pharmacol. 1978 Mar 15;48(2):143-50. doi: 10.1016/0014-2999(78)90323-0.

Abstract

The effects of hydralazine upon the caudal pressor responses during occlusion of the abdominal aorta and vena cava evoked by: (1) preganglionic electrical stimulation of the lumbar sympathetic chain, (2) neostigmine and (3) McN-A-343 were investigated in the anesthetized dog. Hydralazine (10 microgram/kg, i.v.) produced a small but significant reduction of the pressor response to lumbar electrical stimulation prior and following blockade of nicotinic transmission with chlorisondamine (1.0 mg/kg). However, hydralazine was not effective in blocking the pressor responses elicited by neostigmine and McN-A-343. On the other hand, small doses of atropine (20 microgram/kg) produced a blockade of residual pressor responses evoked by all three stimuli. On the basis of these findings, the site of action of hydralazine appears to be different from that of atropine. It is proposed that hydralazine affects ganglionic transmission by acting at sites other than muscarinic in nature.

摘要

研究了肼屈嗪对麻醉犬在以下情况诱发的腹主动脉和腔静脉闭塞时尾部升压反应的影响

(1) 腰交感神经链节前电刺激，(2) 新斯的明，(3) McN-A-343。用氯筒箭毒碱（1.0mg/kg）阻断烟碱传递之前和之后，静脉注射肼屈嗪（10μg/kg）使对腰电刺激的升压反应出现小幅但显著的降低。然而，肼屈嗪对新斯的明和 McN-A-343 引发的升压反应无效。另一方面，小剂量阿托品（20μg/kg）可阻断由所有三种刺激诱发的残余升压反应。基于这些发现，肼屈嗪的作用部位似乎与阿托品不同。有人提出，肼屈嗪通过作用于本质上不是毒蕈碱的部位来影响神经节传递。