Wang C, Chai L, Zhu G
Shanghai Institute of Immunology, Shanghai Second Medical University.
Zhonghua Zhong Liu Za Zhi. 1995 Jan;17(1):27-9.
Our results suggest that the growth of tumors was significantly suppressed when the high-dose rIL-2 (2 x 10(4)U/day) was injected i.p. in mice bearing subcutaneously (s. c.) transplanted tumors. The inhibition effect on the growth of mouse hepatoma HAC was more potent than that on S180 group. It was found that rIL-2 increased significantly the survival of BALB/C mice bearing HAC tumor (P < 0.001). We have also shown that the adoptive transfer of unfractionated LAK cells plus rIL-2 was more effective than rIL-2 alone. The results also indicated that adherent LAK cells (A-LAK) in combination with rIL-2 had higher antitumor effects as compared to standard LAK cells plus rIL-2.
我们的结果表明，当对皮下移植有肿瘤的小鼠腹腔注射高剂量重组白细胞介素-2（2×10⁴U/天）时，肿瘤生长受到显著抑制。对小鼠肝癌HAC生长的抑制作用比对S180组更强。发现重组白细胞介素-2显著提高了荷HAC肿瘤的BALB/C小鼠的存活率（P<0.001）。我们还表明，未分级的淋巴因子激活的杀伤细胞（LAK细胞）加重组白细胞介素-2的过继转移比单独使用重组白细胞介素-2更有效。结果还表明，与标准LAK细胞加重组白细胞介素-2相比，贴壁LAK细胞（A-LAK）与重组白细胞介素-2联合使用具有更高的抗肿瘤效果。
