Liu X, An H, Jiang Y
First Hospital, Xi'an Medical University.
Zhonghua Zhong Liu Za Zhi. 1995 Mar;17(2):97-9.
The serum levels of soluble interleukin 2 receptor (sIL-2R) before and after radiotherapy in 57 esophageal carcinoma patients and 20 healthy controls were determined with an enzyme-linked immunosorbent assay. The objectives of this study were to determine the value of serum SIL-2R level as an index of tumor burden, and its predictive value in response to therapy and prognosis. The data showed that the serum sIL-2R level in esophageal carcinoma patients was significantly higher than that of healthy controls (P < 0.001). The elevated serum sIL-2R levels correlated with the length of the esophageal cancer. The serum levels of sIL-2R were significantly reduced at the end of radiotherapy (P < 0.001). Moreover, the serum level after radiotherapy was not different from that of healthy controls (P > 0.05). But, the reduced levels were not related to the immediate response to radiotherapy. These results seem to suggest that monitoring serum sIL-2R levels has clinical and prognostic significance in patients with esophageal carcinoma.
采用酶联免疫吸附测定法测定了57例食管癌患者和20例健康对照者放疗前后血清可溶性白细胞介素2受体（sIL-2R）水平。本研究的目的是确定血清SIL-2R水平作为肿瘤负荷指标的价值及其对治疗反应和预后的预测价值。数据显示，食管癌患者血清sIL-2R水平显著高于健康对照者（P<0.001）。血清sIL-2R水平升高与食管癌长度相关。放疗结束时血清sIL-2R水平显著降低（P<0.001）。此外，放疗后血清水平与健康对照者无差异（P>0.05）。但是，降低的水平与放疗的即时反应无关。这些结果似乎表明，监测血清sIL-2R水平对食管癌患者具有临床和预后意义。
