Algaba F, Trias I, Lopez L, Rodriguez-Vallejo J M, Gonzalez-Esteban J
Section of Pathology, Fundació Puigvert, Barcelona, Espaãna.
Eur Urol. 1995;27(4):329-33. doi: 10.1159/000475191.
The neuroendocrine cells (NCs) in the peripheral prostatic zone of 32 patients without prostatic symptoms and with an average age of 61.4 +/- 6.7 (range 48-75) years were studied, and it was found that most are closed-type cells (95.8%) and that there is a gradual fall both in their total number and the number per square millimeter (p = 0.03) with advancing age. There were microscopic foci of high-grade prostatic intraepithelial neoplasia (PIN) in 59.3% of the patients and occult carcinomas in 28.1%, but no statistical relationship was found between these lesions and the number of NCs (p = 0.35 and p = 0.9, respectively). The gradual increase in NCs in the peripheral zone of normal prostates as of adolescence, reported in the literature, would appear to support a possible androgenic action on these cells. Our finding of a decrease in patients with foci of PIN and carcinoma from the fifth decade suggests that this decrease in NCs may make the prostate more susceptible to carcinogenic factors.
对32例无前列腺症状、平均年龄61.4±6.7岁（范围48 - 75岁）患者外周前列腺区的神经内分泌细胞（NCs）进行了研究，发现大多数为封闭型细胞（95.8%），并且随着年龄增长，其总数和每平方毫米的数量均逐渐下降（p = 0.03）。59.3%的患者存在高级别前列腺上皮内瘤变（PIN）的微小病灶，28.1%的患者存在隐匿性癌，但未发现这些病变与NCs数量之间存在统计学关系（分别为p = 0.35和p = 0.9）。文献报道青春期后正常前列腺外周区NCs逐渐增加，这似乎支持雄激素对这些细胞可能有作用。我们发现从五十多岁起，有PIN病灶和癌的患者中NCs减少，这表明NCs的这种减少可能使前列腺更容易受到致癌因素的影响。
