Sedo A, Pegoraro S, Rovero P, Revoltella R P
1st Department of Medical Chemistry and Biochemistry, 1st Medical Faculty, Charles University, Praha, Czech Republic.
Folia Biol (Praha). 1995;41(2):97-105.
A series of C-terminal linear endothelin analogues were prepared and their activities in C6 rat glioma cell line were tested. Among the synthetic analogues, IBDP 064, Fmoc-Leu-Asp-Ile-Ile-Trp-OH, was the most potent and selective inhibitor of endothelin-3-induced cell proliferation. Its action was comparable with that of the previously described peptide IRL 1038, [Cys11-Cys15]-ET-1(11-21), an ETB specific inhibitor.
