Sundler F, Andersson K, Mattsson H
Department of Medical Cell Research, University of Lund, Sweden.
Digestion. 1995;56(3):194-8. doi: 10.1159/000201242.
Inhibition of acid secretion with high doses of antisecretagogues, such as omeprazole, is known to raise the plasma gastrin levels. In the present study, we examined the effect of long-term (1-year) treatment of female rats with high doses of omeprazole on the density of antral gastrin and somatostatin cells. A possible effect on the endocrine cell density (chromogranin A as marker) and mucosal thickness of the colon was also examined. The plasma gastrin level in the omeprazole-treated rats was increased 15-fold compared with the level in the controls. The gastrin cell density, on the other hand, showed only a 2-fold increase. The somatostatin cell density in the omeprazole-treated rats was half that in the controls, indicating an inverse relationship between antral gastrin and somatostatin. In the colonic mucosa, neither the mucosal thickness nor the number of chromogranin-A-containing endocrine cells were affected by the omeprazole-induced hypergastrinemia. The results indicate that long-term acid inhibition results in a sustained hypergastrinemia, a modest and stable antral gastrin cell hyperplasia, antral somatostatin cell hypoplasia and lack of trophic effects in the colon.
已知使用高剂量的抗分泌剂（如奥美拉唑）抑制胃酸分泌会提高血浆胃泌素水平。在本研究中，我们检测了用高剂量奥美拉唑长期（1年）治疗雌性大鼠对胃窦胃泌素和生长抑素细胞密度的影响。还检测了其对结肠内分泌细胞密度（以嗜铬粒蛋白A为标志物）和黏膜厚度的可能影响。与对照组相比，用奥美拉唑治疗的大鼠血浆胃泌素水平增加了15倍。另一方面，胃泌素细胞密度仅增加了2倍。用奥美拉唑治疗的大鼠生长抑素细胞密度是对照组的一半，表明胃窦胃泌素和生长抑素之间呈负相关。在结肠黏膜中，黏膜厚度和含嗜铬粒蛋白A的内分泌细胞数量均未受奥美拉唑诱导的高胃泌素血症影响。结果表明，长期抑制胃酸会导致持续的高胃泌素血症、适度且稳定的胃窦胃泌素细胞增生、胃窦生长抑素细胞发育不全以及结肠缺乏营养作用。
