Hong E, Castillo C, Flores E, Mercedes F
Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, San Pedro de Macoris, República Dominicana.
Gac Med Mex. 1994 May-Jun;130(3):131-3.
The seronin or 5-hydroxytryptamine (5-HT) is a biogenic amine involved in diverse physiologic and physiopathological processes in the cardiovascular system. 5-HT may lower the arterial blood pressure by an action on central 5-HT1A receptors, or may increase it by stimulation of 5-HT2 receptors located in vascular smooth muscle. It has been postulated that hypofunction of 5-HT1A receptors, or the exaggerated stimulation of 5-HT2 receptor may be associated with arterial hypertension and that agonists of the first type (indorenate or 8-OH-DPAT) or antagonists of the second type (ketanserin or pelanserin) allow the control of arterial hypertension. On the other land, ketanserin and pelanserin attenuated the hemodynamic manifestations in an experimental model of thromboembolism, suggesting that 5-HT is involved in such phenomenon. Finally, 5-HT could be related with the presence of angor pectoris during hypertension or atherosclerosis, diseases that are associated with a lesional of the vascular endothelium, a condition that favors the 5-HT induced vasoconstriction in coronary arteries.
血清素或5-羟色胺（5-HT）是一种生物胺，参与心血管系统的多种生理和病理生理过程。5-HT可通过作用于中枢5-HT1A受体降低动脉血压，或通过刺激血管平滑肌中的5-HT2受体升高血压。据推测，5-HT1A受体功能减退或5-HT2受体过度刺激可能与动脉高血压有关，第一类激动剂（吲哚雷尼或8-OH-DPAT）或第二类拮抗剂（酮色林或培拉色林）可控制动脉高血压。另一方面，酮色林和培拉色林在血栓栓塞实验模型中减轻了血流动力学表现，表明5-HT参与了这种现象。最后，5-HT可能与高血压或动脉粥样硬化期间心绞痛的发生有关，这些疾病与血管内皮损伤有关，而这种情况有利于5-HT诱导的冠状动脉血管收缩。
