Gómez M, Navarro P, Cano A
Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, España.
Invasion Metastasis. 1994;14(1-6):17-26.
The expression and organization of the extracellular matrix component fibronectin has been analyzed in a collection of murine epidermal keratinocyte cell lines representative of different stages of mouse skin carcinogenesis. The fibroblastoid phenotype of spindle cells has been found to be associated with high levels of fibronectin expression and the ability to organize this molecule in an extracellular matrix. These observations, together with our previous analysis on the expression of cadherins, alpha 6 beta 4 integrin and the proteoglycan syndecan, indicate that profound alterations in cell adhesion behaviour occur in the last stages of tumor progression in this system. These alterations could favor the migratory and invasive phenotype of spindle cells.
在一组代表小鼠皮肤癌发生不同阶段的鼠表皮角质形成细胞系中，对细胞外基质成分纤连蛋白的表达和组织情况进行了分析。已发现梭形细胞的成纤维细胞样表型与高水平的纤连蛋白表达以及在细胞外基质中组织该分子的能力相关。这些观察结果，连同我们之前对钙黏蛋白、α6β4整合素和蛋白聚糖多配体蛋白聚糖表达的分析，表明在该系统中肿瘤进展的最后阶段发生了细胞黏附行为的深刻改变。这些改变可能有利于梭形细胞的迁移和侵袭表型。
