Strømsøe K, Høiseth A, Alho A, Kok W L
Ullevål Hospital, University of Oslo, Norway.
J Biomech. 1995 Jul;28(7):857-61. doi: 10.1016/0021-9290(95)95274-9.
To analyze the importance of bone mineral for the strength of the distal diaphyseal femur, we studied 14 distal cadaver femora by quantitative computed tomography, (QCT) dual energy X-ray (DXA) absorptiometry and three-point bending. The femora were retrieved at autopsy from 10 male and 4 female donors aged median 74 yr (range 59-92 yr). Significant correlations were found between three bone mineral mass related parameters--QCT bone mass (density x slice area), DXA mineral density (BMD) and content (BMC)--and mechanical parameters. Second area moment equivalents correlated significantly with the mechanical properties of the distal femur. QCT density did not show the same high correlations. The results indicate that the structural strength of diaphyseal bone is determined more by its geometry than mineral density. Assessment of bone mass by QCT or DXA may become important not only for assessment of fracture risk but also for planning of internal fixation in the treatment of osteporotic fractures. Further studies are required to investigate the clinical importance of these observations.
为分析骨矿物质对股骨远端骨干强度的重要性，我们通过定量计算机断层扫描（QCT）、双能X线（DXA）吸收法和三点弯曲试验研究了14具尸体的股骨远端。这些股骨是在尸检时从10名男性和4名女性供体中获取的，供体年龄中位数为74岁（范围59 - 92岁）。在三个与骨矿物质质量相关的参数——QCT骨质量（密度×切片面积）、DXA矿物质密度（BMD）和含量（BMC）——与力学参数之间发现了显著相关性。二阶面积矩当量与股骨远端的力学性能显著相关。QCT密度并未显示出同样高的相关性。结果表明，骨干骨的结构强度更多地由其几何形状而非矿物质密度决定。通过QCT或DXA评估骨质量不仅对于评估骨折风险可能很重要，而且对于骨质疏松性骨折治疗中的内固定规划也可能很重要。需要进一步研究来探讨这些观察结果的临床重要性。
