Gleicher N, Campbell D P, Chan C L, Karande V, Rao R, Balin M, Pratt D
Division of Reproductive Endocrinology and Infertility, Center for Human Reproduction, Chicago, IL 60610, USA.
Hum Reprod. 1995 May;10(5):1079-84. doi: 10.1093/oxfordjournals.humrep.a136098.
Paradoxically, the attitude of infertility patients towards multiple births has never been investigated. We therefore generated a survey by questionnaire, which was sent to 3800 consecutive unselected couples with infertility problems: 582 responses were received (15% response rate) and analysed. The percentage distribution of the responses to 21 questions, addressing attitudes towards and knowledge about the risk of multiple gestations, was the main outcome. Worry about multiple births was expressed, independent of the number of multiples, although fear about multiple conceptions was rejected by a large majority (64%). The risk of a twin birth was not strongly perceived, but the perception of risk increased with increasing numbers of multiples: triplets (50-62%), quadruplets or more (71-72%). A desire for the conception of twins was expressed by 67-90% of couples, a desire for the conception of triplets was equally expressed and rejected, and for a multiple gestation beyond triplets was rejected by 73-82% of couples. Patients were educated about the risks of selective embryo reduction and responded in a bimodal fashion to the option of utilizing this procedure, with equal numbers being willing to consider or reject it. Age, parity and length of infertility did not affect the couples' worry or fear about multiples. The desire for twins and triples, however, was correlated significantly with age (twins, P = 0.032; triplets, P = 0.03); there was no such correlation for larger multiples. The length of infertility was correlated with a positive attitude towards multiples beyond triplets (P = 0.029) but was not correlated with a desire for twins or triplets. Prior parity did not affect the attitude towards multiples at all.(ABSTRACT TRUNCATED AT 250 WORDS)
矛盾的是，从未有人调查过不孕患者对多胎妊娠的态度。因此，我们通过问卷调查开展了一项研究，向3800对连续就诊的、未经过筛选的不孕夫妇发放了问卷：共收到582份回复（回复率为15%）并进行了分析。对21个问题的回复的百分比分布是主要研究结果，这些问题涉及对多胎妊娠风险的态度和认识。尽管绝大多数人（64%）不担心多胎受孕，但无论多胎数量多少，人们都表达了对多胎妊娠的担忧。双胞胎出生的风险并未被强烈感知，但随着多胎数量的增加，对风险的感知也会增加：三胞胎（50 - 62%）、四胞胎及以上（71 - 72%）。67 - 90%的夫妇表示希望怀上双胞胎，对怀上三胞胎的意愿表达和反对的比例相当，而73 - 82%的夫妇反对怀上三胞胎以上的多胎妊娠。患者接受了关于选择性减胎风险的教育，并对采用该程序的选择给出了双峰式的回应，愿意考虑或拒绝的人数相等。年龄、产次和不孕时间并未影响夫妇对多胎妊娠的担忧或恐惧。然而，对双胞胎和三胞胎的渴望与年龄显著相关（双胞胎，P = 0.032；三胞胎，P = 0.03）；对于更多胎次的情况则不存在这种相关性。不孕时间与对三胞胎以上多胎妊娠的积极态度相关（P = 0.029），但与对双胞胎或三胞胎的渴望无关。既往产次根本不影响对多胎妊娠的态度。（摘要截选至250词）
