Dubuisson J B, Chapron C, Nos C, Morice P, Aubriot F X, Garnier P
Service de Chirurgie Gynecologique, Clinique Universitaire Baudelocque, C.H.U. Cochin Port-Royal, Paris, France.
Hum Reprod. 1995 May;10(5):1145-51. doi: 10.1093/oxfordjournals.humrep.a136108.
Fertility outcome following sterilization reversal by laparotomy was evaluated. We studied all sterilization reversals performed between January 1978 and December 1991; a total of 226 women were treated. Tubal anastomosis was performed according to the rules for microsurgery. The microsurgical technique comprised two main phases: preparation of the healthy tube segments and the anastomosis carried out on two layers. It was possible to study the subsequent fertility of 206 patients in all, as 20 patients were lost to follow-up (8.8%). Cumulative pregnancy rates were evaluated by life-table analysis. The overall intrauterine pregnancy rate, including births and miscarriages, was 69.9% (144 patients) after 2 years. The cumulative intrauterine pregnancy rate was 62% at 18 months. Analysis of the fertility results demonstrated that age was the most significant predictive factor. The cumulative intrauterine pregnancy rate at 2 years was 83.5% (61 cases) for patients < or = 33 years, 70% (35 cases) for patients aged 34-36 years, 62.5% (30 cases) for patients aged 37-39 years, and 51.4% (18 cases) for patients aged > or = 40 years. Even for patients aged approximately 40 years, microsurgical repermeabilization can be retained as the first choice rather than in-vitro fertilization.
评估了经剖腹手术进行输卵管复通术后的生育结局。我们研究了1978年1月至1991年12月期间所有进行的输卵管复通术;共有226名女性接受了治疗。输卵管吻合术按照显微外科手术规则进行。显微外科技术包括两个主要阶段:健康输卵管段的制备以及分两层进行的吻合术。总共能够研究206例患者的后续生育情况,因为有20例患者失访(8.8%)。通过寿命表分析评估累积妊娠率。2年后,包括分娩和流产在内的总体宫内妊娠率为69.9%(144例患者)。18个月时累积宫内妊娠率为62%。对生育结果的分析表明,年龄是最显著的预测因素。年龄≤33岁的患者2年后累积宫内妊娠率为83.5%(61例),34 - 36岁的患者为70%(35例),37 - 39岁的患者为62.5%(30例),年龄≥40岁的患者为51.4%(18例)。即使对于年龄约40岁的患者,显微外科再通术仍可作为首选,而非体外受精。