Marak G E
Mod Probl Ophthalmol. 1976;16:102-5.
The long held notion that sympathetic ophthalmia represents an autoimmune reaction to uveal pigment is no longer tenable. Pigmentation influences the histopathologic picture of sympathetic ophthalmia but no evidence supports the role of uveal pigment as inciting antigen. Several recent studies have confirmed our initial report of the participation of cellular hypersensitivity to ocular tissues in the pathogenesis of this disease. Both clinical and experimental studies implicate retinal tissue as being more immunogenic than uveal antigens. The recent histopathologic observation that eosinophils concentrate near the choriocapillaris suggests that outer retina and retinal pigment epithelium should not be overlooked as a potential source of the stimulating antigen in sympathetic ophthalmia.
长期以来认为交感性眼炎是对葡萄膜色素的自身免疫反应这一观念已不再成立。色素沉着会影响交感性眼炎的组织病理学表现，但没有证据支持葡萄膜色素作为激发抗原的作用。最近的几项研究证实了我们最初关于细胞对眼组织的超敏反应参与该病发病机制的报道。临床和实验研究均表明视网膜组织比葡萄膜抗原更具免疫原性。最近的组织病理学观察发现嗜酸性粒细胞聚集在脉络膜毛细血管附近，这表明外层视网膜和视网膜色素上皮作为交感性眼炎中刺激抗原的潜在来源不应被忽视。
