Borin M T, Driver M R, Forbes K K
Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan 49001-0199, USA.
J Clin Pharmacol. 1995 May;35(5):505-9. doi: 10.1002/j.1552-4604.1995.tb04095.x.
The effect of a high-fat meal and the timing of this meal on the absorption of a 400-mg oral dose of cefpodoxime proxetil was evaluated in 20 healthy, adult, male volunteers in a four-way crossover study. The area under the plasma concentration-time curve, peak plasma concentration, and urinary recovery were significantly greater (P = .0001) after administration of cefpodoxime proxetil tablets with and 2 hours after a meal relative to dosing under fasted conditions or 1 hour before a meal. The time to peak concentration did not differ significantly among treatments, which suggests that food did not affect the rate of drug absorption. These results indicate that absorption of cefpodoxime proxetil is enhanced when tablets are taken with food or shortly after a meal.
在一项四交叉研究中，对20名健康成年男性志愿者评估了高脂餐及其用餐时间对口服400毫克头孢泊肟酯吸收的影响。与空腹给药或用餐前1小时给药相比，在用餐时及用餐后2小时服用头孢泊肟酯片后，血浆浓度-时间曲线下面积、血浆峰浓度和尿回收率显著更高（P = 0.0001）。各治疗组的达峰时间无显著差异，这表明食物不影响药物吸收速率。这些结果表明，用餐时或用餐后不久服用头孢泊肟酯片时，其吸收会增强。
