Demonstration of cell-mediated immunological reactivity to transplantation antigens in uveo-retinal tissues.

Lymph node cells from inbred rats, sensitized against allotransplantation antigens, were tested for reactivity against uveo-retinal tissues, using a two-step leucocyte migration inhibition test: (1) These tissues induced positive reactions indicating the presence of transplantation antigens. (2) This was true for strong and weaker histoincompatibility systems. (3) Quantitatively, uveo-retinal tissues were somewhat less reactive than lymphocytes as antigen.