Akinbi H T, Gerdes J S
Pennsylvania Hospital, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia 19107, USA.
J Pediatr. 1995 Sep;127(3):481-4. doi: 10.1016/s0022-3476(95)70087-0.
C-peptide concentrations in the cord blood of 29 macrosomic neonates born of nondiabetic mothers were higher than in 23 control infants whose birth weight was appropriate for gestational age, and there was a significant direct correlation between birth weight and C-peptide concentration. Six of the macrosomic infants studied (20%) had hypoglycemia in the first 24 hours of life, compared with none of the infants born with appropriate weight. We conclude that chronic fetal hyperinsulinemia may be one of the causes of macrosomia and neonatal hypoglycemia in infants of nondiabetic mothers.
29名非糖尿病母亲所生巨大儿的脐血C肽浓度高于23名出生体重与孕周相符的对照婴儿，且出生体重与C肽浓度之间存在显著的正相关。研究的巨大儿中有6名（20%）在出生后24小时内出现低血糖，而出生体重正常的婴儿无一出现低血糖。我们得出结论，慢性胎儿高胰岛素血症可能是非糖尿病母亲婴儿巨大儿和新生儿低血糖的原因之一。
