Rubio C A, Jass J R, King A
Department of Pathology, Auckland University, School of Medicine, Auckland and Middlemore Hospital, Otahuhu, New Zealand.
J Environ Pathol Toxicol Oncol. 1994;13(4):243-9.
Previous studies have indicated that the frequency of different cell phenotypes as well as of the mucosal extension of intestinal metaplasia (IM) in the gastric mucosa varies in different geographic regions (Scandinavia, Japan, Mexico, Hawaii, and mainland U.S.A.). These variations appear to be influenced by environmental factors but not by the race of the individuals. In the present work, 241 gastrectomy specimens from the two main racial groups in New Zealand, indigenous Pacific Island Polynesians (mainly Maoris) and non-Polynesian settlers (mainly of European ancestry), were examined. The occurrence of histologic changes known to be influenced by the environment such as intramucosal gastric cysts, intestinal metaplasia (IM), ciliated metaplastic cells, and cells with large vacuoles were recorded. The mucosal extension of IM was classified into low IM (having one to five areas with IM in at least one of the sections) and high IM (having one area with IM in all microscopic fields in at least one of the sections or occupying entire fields in one or more sections). Polynesians with adenocarcinomas and peptic ulcers were younger than non-Polynesians. The gastric mucosa in younger Polynesians harboring an intestinal type carcinoma or a peptic ulcer differed from that of non-Polynesians; Polynesians more often had intramucosal cysts, high IM scores, or ciliated metaplastic cells at a younger age than non-Polynesians. These results suggest that the gastric mucosa of Polynesians may be exposed to environmental factors (ulcerogenic or carcinogenic) at an earlier age than the gastric mucosa of non-Polynesians in New Zealand.
先前的研究表明，不同地理区域（斯堪的纳维亚、日本、墨西哥、夏威夷和美国本土）胃黏膜中不同细胞表型的频率以及肠化生（IM）的黏膜扩展情况有所不同。这些差异似乎受环境因素影响，而非个体种族。在本研究中，对来自新西兰两个主要种族群体的241份胃切除标本进行了检查，这两个群体分别是太平洋岛屿原住民波利尼西亚人（主要是毛利人）和非波利尼西亚定居者（主要是欧洲血统）。记录了已知受环境影响的组织学变化的发生情况，如黏膜内胃囊肿、肠化生（IM）、纤毛化生细胞和有大液泡的细胞。IM的黏膜扩展分为低级别IM（在至少一个切片中有1至5个IM区域）和高级别IM（在至少一个切片的所有显微镜视野中有1个IM区域，或在一个或多个切片中占据整个视野）。患有腺癌和消化性溃疡的波利尼西亚人比非波利尼西亚人年轻。患有肠型癌或消化性溃疡的年轻波利尼西亚人的胃黏膜与非波利尼西亚人不同；与非波利尼西亚人相比，波利尼西亚人在更年轻时更常出现黏膜内囊肿、高级别IM评分或纤毛化生细胞。这些结果表明，与新西兰的非波利尼西亚人相比，波利尼西亚人的胃黏膜可能在更早的年龄就暴露于环境因素（致溃疡或致癌因素）。
