Otsuka M, Matsumoto T, Higuchi S, Otsuka K, Kaneniwa N
Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Japan.
J Pharm Sci. 1995 May;84(5):614-8. doi: 10.1002/jps.2600840517.
The effect of environmental temperature on the compression mechanism of chlorpropamide (CPM) polymorph, forms A and C, was investigated with an eccentric type tabletting machine with two load cells and a noncontact displacement transducer. The temperature of the die was controlled at 0 and 45 degrees C by a thermocontroller. Sample powders (200 mg), which were also controlled at 0 and 45 degrees C by a thermocontroller, were compressed at almost 230 MPa. The tabletting dynamic processes of CPM forms A and C at 0 and 45 degrees C were evaluated by Cooper and modified Heckel analyses. The results suggest that particle brittleness or plasticity was affected by compression at different temperatures. The higher tablet hardness of form A at 45 degrees C was thought to be caused by the increased plasticity of primary particles, whereas that of form C at 45 degrees C was ascribed to the decreased size of the secondary particles.
采用配有两个测力传感器和一个非接触式位移传感器的偏心式压片机，研究了环境温度对氯磺丙脲（CPM）多晶型物A和C压缩机制的影响。通过热控制器将模具温度控制在0℃和45℃。同样通过热控制器将样品粉末（200mg）也控制在0℃和45℃，并在近230MPa下进行压缩。通过库珀分析和修正的赫克尔分析评估了CPM晶型A和C在0℃和45℃下的压片动态过程。结果表明，在不同温度下压缩会影响颗粒的脆性或塑性。45℃时晶型A较高的片剂硬度被认为是由初级颗粒可塑性增加所致，而45℃时晶型C的片剂硬度则归因于次级颗粒尺寸减小。
