O'Connell H E, McGuire E J, Aboseif S, Usui A
Division of Urology, University of Texas-Houston, Medical School, USA.
J Urol. 1995 Oct;154(4):1463-5.
We evaluated our recent experience with transurethral collagen therapy in women.
A series of 44 women with video urodynamic evidence of intrinsic sphincter deficiency were treated with transurethral collagen therapy using local anesthesia. Median patient age was 72 years (range 41 to 94). Mean duration of incontinence was 72 months. Incontinence was grade 3 in 42 patients. Mean abdominal leak point pressure before treatment was 56 cm. water. Patient response to treatment was evaluated by the change in the number of pads required to effect significant improvement.
Median number of pads used was 5 pretreatment (range 3 to 12) and 3 posttreatment. A total of 20 patients was cured and 8 others required only 1 pad daily after treatment (63% cured or needing no pads daily). Of the cured patients 4 had used greater than 10 pads daily before collagen injection. One treatment was given to 22 patients and 7 have not improved of whom 2 underwent only 1 treatment. Mean volume of collagen used to effect a cure was 9.1 cc.
Collagen injection is a useful treatment for the severely incontinent female patient with intrinsic sphincter deficiency.
我们评估了近期女性经尿道胶原蛋白治疗的经验。
对44例经视频尿动力学检查证实存在固有括约肌功能不全的女性患者，采用局部麻醉行经尿道胶原蛋白治疗。患者年龄中位数为72岁（范围41至94岁）。尿失禁平均持续时间为72个月。42例患者尿失禁为3级。治疗前平均腹压漏尿点压力为56 cm水柱。通过改善明显所需护垫数量的变化来评估患者对治疗的反应。
治疗前使用护垫的中位数为5片（范围3至12片），治疗后为3片。共有20例患者治愈，另外8例患者治疗后每天仅需1片护垫（63%治愈或无需每日使用护垫）。在治愈的患者中，4例在注射胶原蛋白前每天使用超过10片护垫。22例患者接受了1次治疗，7例无改善，其中2例仅接受了1次治疗。治愈所需胶原蛋白的平均用量为9.1 cc。
胶原蛋白注射是治疗严重尿失禁且存在固有括约肌功能不全的女性患者的一种有效治疗方法。
