Achilles W, Freitag R, Kiss B, Riedmiller H
Universitätsklinikum Marburg, Urologische Klinik, Marburg/Lahn, Germany.
J Urol. 1995 Oct;154(4):1552-6.
To use a new flow model of crystallization to quantify the growth of calcium oxalate monohydrate (COM) in a gel matrix under simulated physiological conditions.
Artificial urine supersaturated in COM was conducted through channels containing a gel with COM seed crystals (flow rate: 0.5 ml. per minute; reaction time: 4 hours; 37 +/- 1C). A relative crystal growth parameter, Vcr, was quantified by discontinuous measurement of scattered light intensity by microphotometry. The effects on Vcr of varying a series of urinary parameters were investigated within the system.
The following order of effectiveness in changing COM growth could be derived: dilution > oxalate > calcium > magnesium approximately citrate.
Drinking therapy and lowering of urinary oxalate excretion can be concluded to be the most promising means of preventing CaOx urolithiasis. The new crystallization model demonstrated here should be suitable to new applications in the investigation of urinary stone formation.
使用一种新的结晶流动模型，在模拟生理条件下对凝胶基质中一水草酸钙（COM）的生长进行量化。
使COM过饱和的人工尿液通过含有COM籽晶的凝胶通道（流速：每分钟0.5毫升；反应时间：4小时；37±1℃）。通过显微光度法对散射光强度进行间断测量，从而量化相对晶体生长参数Vcr。在该系统内研究了一系列尿液参数变化对Vcr的影响。
得出改变COM生长的有效性顺序如下：稀释＞草酸盐＞钙＞镁≈柠檬酸盐。
可以得出饮水疗法和降低尿草酸盐排泄是预防草酸钙尿路结石最有前景的方法。此处展示的新结晶模型应适用于尿路结石形成研究中的新应用。
