Embon C M, Goldstein K L, Hall M R, Leu B B, Saboe G, Smith B A
Neonatal Netw. 1995 Sep;14(6):7-14.
Congenital leukemia is a rare hematological disorder. The initial manifestation of the disease may be the presence of blue or gray skin nodules. The presence of these nodules along with hyperleukocytosis, anemia, hepatosplenomegaly, and central nervous system leukemic involvement are characteristic of the disease. Treatment involves the administration of chemotherapy by protocol. Response to the chemotherapy is generally poor. Infants with Down syndrome may have a transient manifestation of leukemia known as a leukemic disorder; this will resolve without chemotherapy. Other neonatal disorders can also mimic congenital leukemia; the infant must be evaluated for these, in addition to the definitive diagnosis made via bone marrow aspiration and examination. There are many nursing care interventions for the infant with suspected congenital leukemia. The family of an infant with a suspected or diagnosed leukemia requires concrete information and psychosocial support because the prognosis for these infants is grave. We describe the level of care and subsequent outcome for a premature infant who was diagnosed with congenital leukemia and treated with chemotherapy in a Level III nursery.
先天性白血病是一种罕见的血液系统疾病。该疾病的初始表现可能是皮肤出现蓝色或灰色结节。这些结节的存在，以及白细胞增多、贫血、肝脾肿大和中枢神经系统白血病浸润，是该疾病的特征。治疗包括按照方案进行化疗。化疗反应通常较差。患有唐氏综合征的婴儿可能会有白血病的短暂表现，称为白血病性疾病；这种情况无需化疗即可自行缓解。其他新生儿疾病也可能模仿先天性白血病；除了通过骨髓穿刺和检查做出明确诊断外，还必须对婴儿进行这些疾病的评估。对于疑似先天性白血病的婴儿，有许多护理干预措施。疑似或确诊白血病的婴儿家庭需要具体信息和心理社会支持，因为这些婴儿的预后很差。我们描述了一名在三级新生儿重症监护病房被诊断为先天性白血病并接受化疗的早产儿的护理水平和后续结果。
