Gaydos C A, Gaydos J C
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Mil Med. 1995 Jun;160(6):300-4.
Acute respiratory disease (ARD) due to adenoviruses caused significant morbidity in military training populations. Since 1971 ARD has been controlled by the use of live, enteric-coated, adenovirus (ADV) types 4 and 7 vaccines. This immunization program overcame significant problems in vaccine development. Due to a production delay, military training posts stopped ADV vaccine administration in spring 1994. The delivery of ADV vaccine resumed in late February 1995, but another production delay is anticipated. A generation of military medical people have not been exposed to the significant morbidity caused by adenoviruses and are unaware of the effectiveness of the ADV vaccine. ARD morbidity before ADV vaccines, the ADV vaccine development program, and current issues regarding the control of ARD due to adenoviruses in the military are discussed.
腺病毒引起的急性呼吸道疾病（ARD）在军事训练人群中导致了显著的发病率。自1971年以来，ARD通过使用活的、肠溶包衣的4型和7型腺病毒（ADV）疫苗得到了控制。该免疫计划克服了疫苗开发中的重大问题。由于生产延迟，军事训练基地于1994年春季停止了ADV疫苗的接种。ADV疫苗的供应于1995年2月下旬恢复，但预计还会有另一次生产延迟。一代军事医务人员未曾接触过腺病毒引起的显著发病率，也不知道ADV疫苗的有效性。本文讨论了ADV疫苗出现之前的ARD发病率、ADV疫苗开发计划以及当前军队中腺病毒所致ARD控制方面的问题。
