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用红藻氨酸/喹啉酸受体拮抗剂6-氰基-7-硝基喹喔啉-2,3-二酮长期处理大鼠脑，对新纹状体前脑啡肽原和前速激肽原mRNA丰度的影响

Attenuation of neostriatal preproenkephalin and preprotachykinin mRNA abundance by chronic treatment with the kainate/quisqualate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione in the rat brain.

作者信息

Villegas M, Angulo J A

机构信息

Department of Biological Sciences, Hunter College, City University of New York, NY 10021, USA.

出版信息

Neurosci Lett. 1995 May 19;191(1-2):51-4. doi: 10.1016/0304-3940(95)11556-6.

DOI:10.1016/0304-3940(95)11556-6
PMID:7659290
Abstract

The present investigation assessed the effect of chronic blockade of kainate/quisqualate binding sites with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on preproenkephalin (PPE) and preprotachykinin (PPT) mRNA abundance in the neostriatum of the rat brain. Daily injection of CNQX for seven consecutive days decreased PPE mRNA abundance approximately 25% below vehicle-injected controls in dorsolateral, dorsomedial, anterior caudate-putamen (dlCPu, dmCPu and aCPu, respectively) and nucleus accumbens (NAc). Similarly, PPT mRNA abundance was significantly decreased in dlCPu, dmCPu and aCPu but not in the accumbens. The data demonstrate that non-NMDA receptor activity modulates basal levels of expression of PPE and PPT mRNAs in the neostriatum of the rat brain.

摘要

本研究评估了用6-氰基-7-硝基喹喔啉-2,3-二酮（CNQX）长期阻断大鼠脑海马体中红藻氨酸/使君子氨酸结合位点对前脑啡肽原（PPE）和前速激肽原（PPT）mRNA丰度的影响。连续7天每日注射CNQX，使背外侧、背内侧、前尾状核-壳核（分别为dlCPu、dmCPu和aCPu）以及伏隔核（NAc）中PPE mRNA丰度比注射溶媒的对照组降低约25%。同样，dlCPu、dmCPu和aCPu中的PPT mRNA丰度显著降低，但伏隔核中未降低。数据表明，非NMDA受体活性调节大鼠脑海马体中PPE和PPT mRNA的基础表达水平。

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