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[促性腺激素释放激素类似物在宫腔镜手术中的应用]

[Use of GnRH analogs in hysteroscopic surgery].

作者信息

Celis R

机构信息

Departamento de Ginecología y Obstetricia, Universidad de La Frontera.

出版信息

Rev Chil Obstet Ginecol. 1994;59(2):153-7.

PMID:7659801
Abstract

Hysteroscopic surgery has been widely used in gynaecology for the treatment of endocavitary fibroids, synechias, uterine septum and abnormal uterine bleeding. Reports proposed preoperative medical therapy to improve the endometrials conditions. Attempts at inhibiting the thickness and vascularity of the endometrium and to reduce the fibroids size in preparation for hysteroscopic surgery by using different types of hormones have been reported. The suppression provided for a long period of time after the procedure by gonadotropin releasing hormone (GnRH) analogs, is likely to help inhibit endometrial regeneration and provided even better long time success, in endometrial ablation and submucous leiomyomatas hysteroscopic surgery. A literature review of the efficiency of the gonadotropins releasing hormone agonist, in endometrial inhibition before surgery and small regional experience is shown.

摘要

宫腔镜手术已在妇科广泛用于治疗宫腔内肌瘤、粘连、子宫纵隔和异常子宫出血。有报告提出术前药物治疗以改善子宫内膜状况。据报道,人们尝试使用不同类型的激素来抑制子宫内膜厚度和血管生成,并缩小肌瘤大小,为宫腔镜手术做准备。促性腺激素释放激素(GnRH)类似物在术后提供的长时间抑制,可能有助于抑制子宫内膜再生,并在子宫内膜切除术和黏膜下平滑肌瘤宫腔镜手术中取得更好的长期效果。本文对促性腺激素释放激素激动剂在术前抑制子宫内膜方面的有效性进行了文献综述,并展示了一些小范围的经验。

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