Massardo T, González P, Yovanovich J, Maiers E, Ayala F, Ramírez A, Berr J L, Zamorano J, Humeres P, Muñoz A
Centro de Medicina Nuclear y Cardiovascular, Facultad de Medicina, Hospital Clínico de la Universidad de Chile, Santiago.
Rev Med Chil. 1994 Dec;122(12):1353-61.
We studied left ventricular perfusion and motility in 37 patients with coronary artery disease and disturbances of parietal motility, aged 57 +/- 9 years old, before and after revascularization. Perfusion was assessed with dipyridamole-tc99m MIBI SPECT and motility was assessed with two dimensional echocardiography with amrinone. Myocardial segments were defined as normal, viable or necrotic in both studies. Eighteen subjects were subjected to angioplasty and 19 to coronary bypass surgery. Submitted SPECT and echocardiography were repeated 64 +/- 15 and 69 +/- 23 days after revascularization respectively. The concordance between SPECT and echocardiographic pre-revascularization diagnosis was 60.1% Eighty one percent of segments considered viable with SPECT and 71% thus considered with echocardiography improved after revascularization. Likewise, 50% of segments considered necrotic with SPECT and 68% of segment thus considered with echocardiography did not improve. It is concluded that although there is a good concordance between both methods, they have limitations on the study of myocardial viability and should be considered as second choice.
我们研究了37例冠状动脉疾病伴壁运动障碍患者(年龄57±9岁)血运重建前后的左心室灌注和运动情况。采用双嘧达莫 - 锝99m甲氧基异丁基异腈单光子发射计算机断层扫描(dipyridamole - tc99m MIBI SPECT)评估灌注,并用氨力农二维超声心动图评估运动情况。在两项研究中,心肌节段被定义为正常、存活或坏死。18名受试者接受了血管成形术,19名接受了冠状动脉搭桥手术。血运重建后分别于64±15天和69±23天重复进行SPECT和超声心动图检查。血运重建前SPECT与超声心动图诊断的一致性为60.1%。血运重建后,SPECT认为存活的节段中有81%、超声心动图认为存活的节段中有71%情况有所改善。同样,SPECT认为坏死的节段中有50%、超声心动图认为坏死的节段中有68%情况没有改善。结论是,尽管两种方法之间有良好的一致性,但它们在心肌存活研究方面存在局限性,应被视为第二选择。