Hawgood B J
Toxicon. 1995 May;33(5):591-601. doi: 10.1016/0041-0101(95)00006-8.
One of the great experimentalists in toxinology, Felice Fontana, worked in Tuscany on the venom of the European viper; his classic text Traité sur le Vénin de la Vipère was published in 1781. Fontana identified fundamental questions which he proceeded to test experimentally using as quantitative an approach as possible within the technical confines of the mid to late eighteenth century. Amongst his findings are the discoveries that the constituents of viper venom can be precipitated by alcohol, that the action of the venom is myotoxic and that it produces not only coagulation of blood, but paradoxically, fluidity as well. After more than 200 years, it is time to honour his name and recall his work once more.
毒素学领域伟大的实验学家之一费利切·丰塔纳在托斯卡纳研究欧洲蝰蛇的毒液;他的经典著作《蝰蛇毒液论》于1781年出版。丰塔纳确定了一些基本问题,并在18世纪中后期的技术限制范围内,尽可能采用定量方法进行实验验证。他的发现包括蝰蛇毒液的成分可被酒精沉淀、毒液具有肌毒性,以及它不仅会导致血液凝固,还会产生反常的血液流动性。200多年后,是时候纪念他的名字并再次回顾他的工作了。