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毒液检测试剂盒在巴布亚新几内亚中部省份蛇咬伤治疗中的应用

Venom detection kits in the management of snakebite in Central province, Papua New Guinea.

作者信息

Trevett A J, Lalloo D G, Nwokolo N C, Theakston D G, Naraqi S, Warrell D A

机构信息

Department of Clinical Sciences, University of Papua New Guinea, Port Moresby.

出版信息

Toxicon. 1995 May;33(5):703-5. doi: 10.1016/0041-0101(94)00179-c.

Abstract

The bites of six species of venomous elapid snakes in Central Province Papua New Guinea produce similar clinical syndromes. Optimal management of envenomed patients involves the use of monospecific antivenom. In this study, Venom Detection Kits (VDKs) (CSL Diagnostics, Melbourne) were used to try to make a specific diagnosis in envenomed patients at their admission. VDKs detected venom in admission bite site swabs from 39 to 46 patients (85%). Thirty-eight of these patients were shown to have been bitten by taipans. In all cases where venom was detected by the VDK, this correlated with subsequent laboratory enzyme immunoassay results. Selective use of VDKs in Central Province could allow more widespread use of monospecific antivenoms and produce considerable financial savings.

摘要

在巴布亚新几内亚中部省份,六种有毒眼镜蛇科蛇类的咬伤会产生相似的临床综合征。对中毒患者的最佳治疗方法是使用单特异性抗蛇毒血清。在本研究中,毒液检测试剂盒(VDK,CSL诊断公司,墨尔本)被用于试图在中毒患者入院时做出特异性诊断。VDK在39至46名患者(85%)入院时的咬伤部位拭子中检测到了毒液。其中38名患者被证实是被太攀蛇咬伤。在所有通过VDK检测到毒液的病例中,这与随后的实验室酶免疫分析结果相关。在中部省份选择性使用VDK可以使单特异性抗蛇毒血清得到更广泛的应用,并节省大量资金。

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