包含增殖细胞核抗原假基因的人类基因组DNA片段的核苷酸序列及其在4号染色体上的定位。
Nucleotide sequence of a human genomic DNA fragment containing the PCNA pseudogene and its localization on chromosome 4.
作者信息
Arimori K, Koido S, Yoshimura S, Taniguchi Y, Arimori S, Moriuchi T
机构信息
4th Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
出版信息
Tokai J Exp Clin Med. 1994 Sep;19(1-2):1-5.
A one kb human genomic DNA fragment, containing a processed pseudogene of a proliferating cell nuclear antigen (PCNA/DNA polymerase delta auxiliary protein), was isolated and sequenced. The PCNA pseudogene consisted of the 3' half of exon 4 and the 5' half of exon 5 of the PCNA gene, and shared 84% nucleotide homology with the human PCNA cDNA. The PCNA pseudogene was localized on human chromosome 4, based on data obtained from a panel of human-mouse hybrid cell lines.
分离并测序了一段1千碱基对的人类基因组DNA片段，该片段包含一个增殖细胞核抗原（PCNA/DNA聚合酶δ辅助蛋白）的加工假基因。PCNA假基因由PCNA基因第4外显子的3' 半段和第5外显子的5' 半段组成，与人PCNA cDNA具有84%的核苷酸同源性。根据一组人-鼠杂交细胞系获得的数据，PCNA假基因定位于人类4号染色体上。
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