2-氨基-4-膦酰丁酸对甘氨酸能和γ-氨基丁酸能阻断后视网膜电图关闭反应的影响。
Effect of 2-amino-4-phosphonobutyrate on ERG OFF-response after glycinergic and GABAergic blockade.
作者信息
Popova E, Kupenova P, Vitanova L, Mitova L
机构信息
Department of Physiology, Medical Faculty, Sofia, Bulgaria.
出版信息
Vision Res. 1995 Jul;35(14):1945-9. doi: 10.1016/0042-6989(94)00310-i.
Superfusion with 200 microM 2-amino-4-phosphonobutyrate (APB) of dark and chromatically adapted frog eyecups caused marked potentiation of the ERG OFF-response (d-wave). Blockade of the glycinergic synapses by strychnine did not change this effect at all. Blockade of the GABAergic synapses by picrotoxin slightly diminished the effect of APB in chromatically-adapted eyes with isolated cones' activity, and did not change it in dark-adapted eyes. The results indicate that the action of APB on ERG OFF-response does not depend significantly on GABAergic and glycinergic neurotransmission in frog retina.
用200微摩尔的2-氨基-4-膦酰丁酸（APB）对暗适应和色适应的蛙眼杯进行灌流，可使视网膜电图（ERG）的关闭反应（d波）显著增强。士的宁对甘氨酸能突触的阻断对此效应完全没有影响。苦味毒对GABA能突触的阻断在色适应且有孤立视锥细胞活动的眼中使APB的效应略有减弱，而在暗适应眼中则没有改变。结果表明，APB对ERG关闭反应的作用在很大程度上不依赖于蛙视网膜中的GABA能和甘氨酸能神经传递。
Zotero 插件