Scarpellini F, Mastrone M, Andreoli M, Grazioli M S, Scarpellini L
II Dept. OB/GYN, University La Sapienza, Rome, Italy.
Acta Eur Fertil. 1994 Sep-Oct;25(5):307-9.
To observe if endometrial artificially reproduced cycles were identical to the natural spontaneous ones, we have matched for the endometria of 22 assessed spontaneous ovulating women and 16 postmenopausal ones sequentially treated with exogenous ovarian steroid hormones. The endometrial samples were drawn in the middle luteal phase (20th-22nd of an ideal cycle, 6-8 days from ultrasound assessed ovulation or progesterone exposure), because this is the "implantation window" period. These results can be particularly interesting in the FIV-OD technique that implyes the implantation of the zygote in a fully matured endometrium. Adversely to previous reports there was always an endometrial hystologic lag (2 min.-4 max. days) in all the artificially reproduced cycles observed, while no other endometrial anomalies were found in these last ones. Probably the contrasting results of the previous studies agree with the later timing of endometrial biopsy, because in the late luteal artificially reproduced or spontaneous endometrium there is no hystological difference.
为观察人工诱导的子宫内膜周期是否与自然自发周期相同，我们对22名经评估为自然排卵的女性和16名绝经后女性的子宫内膜进行了匹配，后者接受了外源性卵巢甾体激素的序贯治疗。子宫内膜样本采集于黄体中期（理想周期的第20 - 22天，距超声评估排卵或孕激素暴露6 - 8天），因为这是“着床窗”期。这些结果在涉及将受精卵植入完全成熟子宫内膜的卵泡内体外成熟（FIV - OD）技术中可能特别有趣。与先前的报道相反，在所有观察到的人工诱导周期中，总是存在子宫内膜组织学延迟（2分钟 - 最长4天），而在这些周期中未发现其他子宫内膜异常。先前研究的对比结果可能与子宫内膜活检时间较晚有关，因为在黄体晚期，人工诱导或自然的子宫内膜在组织学上没有差异。
