Torres de Mercau G, Riera de Martínez Villa N, Mercau G A, Martínez Riera N, Soria de Santos N, Vitalone H
Cátedra de Histología-Facultad de Medicina, Universidad Nacional de Tucumán.
Acta Gastroenterol Latinoam. 1995;25(1):35-9.
Saccharin and cyclamates have been proved to cause organic damage. This work attempt to describe drug-induced changes brought about by drugs in 1/1000 saccharin and cyclamate-fed rats for 90 days. The ultrastructural findings show: microvilli hypertrophy; membranous mitochondrial increase in absorptive cells; and secretion changes in calciform cells. Such changes are cell-response phenomena to interference or mutagenic action on nuclear DNA or on cytoplasmatic metabolism.
糖精和甜蜜素已被证明会造成机体损伤。这项研究试图描述在给大鼠喂食含1/1000糖精和甜蜜素的饲料90天后药物引起的变化。超微结构研究结果显示：微绒毛肥大；吸收细胞中的线粒体膜增多；杯状细胞分泌发生变化。这些变化是细胞对核DNA或细胞质代谢受到干扰或诱变作用的反应现象。
